WebApr 10, 2024 · Abnormal regions of hypo-autofluorescence (AF) are a result of decreased levels of lipofuscin, decreased RPE density, or blockage of fluorescence. Some notable causes of hypo-AF include: Decreased RPE lipofuscin (eg RPE atrophy or RPE tears) Presence of naturally occurring macular pigments Acute intraretinal or subretinal … WebApr 12, 2024 · J.A. is a cofounder of iVeena Holdings, iVeena Delivery Systems, and Inflammasome Therapeutics, and he has been a consultant for AbbVie, Allergan, Boehringer-Ingelheim, Olix Pharmaceuticals, Retinal Solutions, and Saksin LifeSciences unrelated to this work. J.A. and B.D.G. are cofounders of DiceRx.
Functions and Diseases of the Retinal Pigment Epithelium
WebMar 15, 2024 · Retinal photoreceptors and RPE cells are especially susceptible to the released iron from metallic intraocular foreign body, as accumulation of intracellular iron in RPE and Müller cells results in retinal siderosis. 27 ERG provides quantitative and objective assessment of retinal dysfunction of the rod and cone systems to guide surgical … WebMar 15, 2016 · RPE dysfunction or death is a primary event in AMD, but the combination(s) of cellular stresses that affect the function and survival of RPE are incompletely understood. Here, using mouse models in which hypoxia can be genetically triggered in RPE, we show that hypoxia-induced metabolic stress alone leads to photoreceptor atrophy. ... d\u0026b scaffolding
Oxidative stress-mediated TXNIP loss causes RPE dysfunction
WebJan 1, 2024 · For example, in retinitis pigmentosa, a disease predominantly of rod dysfunction, FAF may demonstrate a parafoveal ring of increased AF correlating to rod photoreceptor outer segment and secondary RPE dysfunction. 28, 29 Cone dystrophies may demonstrate increased AF of the fovea or a ring of increased AF similar to that seen in … WebNov 14, 2024 · Abstract. The retinal pigment epithelium (RPE), situated upon Bruch's membrane, plays multiple roles in the ocular system by interacting with photoreceptors … WebCentral serous chorioretinopathy (CSR) is a disease characterized by the serous detachment of the neurosensory retina that occurs over an area of leakage from the choriocapillaris through the retinal pigment epithelium (RPE) ( Hussain & Gass 1998; Wang et al. 2008; Yap & Robertson 1996 ). d\u0026b risk analytics dnb.com