Ototoxicity from cisplatin
WebApr 26, 2024 · An overview of cisplatin-associated ototoxicity, namely its clinical features, incidence rates, molecular and cellular mechanisms, and risk factors, is presented and … WebAug 31, 2016 · Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, …
Ototoxicity from cisplatin
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WebApr 5, 2024 · Ototoxicity is defined as damage to structures and function of the auditory-vestibular system caused by exogenous agents, such as chemotherapy. 1 Cisplatin is a … WebMay 19, 2016 · He is actively involved in several human clinical trials looking at the prevention of cisplatin ototoxicity that may drastically decrease the …
WebOf these reactions, cisplatin-induced nephrotoxicity (CIN), cisplatin-induced peripheral neuropathy (CIPN), and cisplatin-induced ototoxicity (CIO) are the three most common of several CITs recognised thus far. While the anti-cancer activity of cisplatin is well understood, the mechanisms driving its toxicities have only begun to be defined. http://mdedge.ma1.medscape.com/fedprac/article/227870/oncology/improving-ototoxicity-monitoring-cisplatin-therapy-va-northeast-ohio
WebObjectives: Cisplatin-induced ototoxicity is a common permanent consequence of curative chemoradiation for locally advanced head and neck squamous cell carcinoma (HNSCC). Predictors of ototoxicity in HNSCC were examined. Materials and methods: In this prospective, observational cohort study, 206 adult HNSCC patients underwent … WebIn cisplatin-treated guinea pigs, pretreatment with A666-DEX-NP effectively preserved OHCs and showed significant hearing protection at 4, 8, and 16 kHz as compared to …
WebJun 3, 2024 · Cisplatin is a chemotherapeutic used in cancer patients to treat solid tumors. It contributes to the approximately 80% five-year survival rate for childhood cancer …
WebMar 6, 2024 · With 74% of testicular cancer survivors reporting hearing loss in a recent study, one expert advised patients to advocate for themselves and their hearing before, during and after cancer treatment with cisplatin-based chemotherapy. Three out of four testicular cancer survivors reported experiencing ototoxicity — damage to the inner ear caused ... health and wellness backgroundWebMar 29, 2024 · Platinum-based agents are a standard chemotherapy treatment for malignancies in both pediatric and adult populations. 1 However, mitigating and managing chemotherapy-associated adverse events remains a concern. 2 Ototoxicity is a well-documented side effect of these platinum-based agents, especially cisplatin. This hearing … health and wellness awareness monthsWebNov 12, 2024 · Commonly reported side effects of cisplatin include: bone marrow depression, nephrotoxicity, and ototoxicity. Continue reading for a comprehensive list of … health and wellness awareness monthWebA clinical and pathologic study of cis-platinum ototoxicity was performed. Twenty-four patients treated with cis-platinum for head and neck cancer were studied prospectively. Post cis-platinum hearing losses were subclinical, detected in 25% of patients, isolated to 4 and 8 kHz, and did not exceed 25 dB at any frequency. golf lessons in perthWebJun 10, 2010 · Objective . Combined cisplatin (CDDP) and radiotherapy is increasingly being used to treat advanced head and neck cancers. As both CDDP and radiation can cause hearing loss, it is important to have a better understanding of the cellular and molecular ototoxic mechanisms involved in combined therapy. Procedure . The effects of CDDP, … golf lessons in phoenixWebCisplatin chemotherapy and surgery are effective treatments for children with standard- ... ototoxicity grading scale was designed. 25 A Brock grade of 0 indicates hearing at less … golf lessons in planoWebCisplatin Ototoxicity. Cisplatin is a widely used and effective drug for the treatment of solid tumors ranging from ovarian, lung, head, and neck to testicular cancer. Dose limiting side … health and wellness banner