Destabilization of medial meniscus
Webdifferences in a destabilized medial meniscus osteoarthritis model. Methods: Male and Female mice receive either a destabilized medial meniscus or sham procedure resulting in groups of n=5 (n=20 total). The mice were then allowed to explore a specialized gait arena to collect spatiotemporal data. Gait results were analyzed for gender differences. WebDestabilization of the medial meniscus (DMM) was performed on the right knees of 2 month-old male Matn1-/- (n = 11) and Matn1+/+ (n = 9) mice. A) mRNA levels of type II …
Destabilization of medial meniscus
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WebApr 10, 2024 · Methods: In the present study, C57BL/6J mice were divided into the following three groups: the sham control, destabilization of the medial meniscus (DMM), and AMD3100-treated DMM (DMM + AMD3100) groups. The mice were sacrificed after 2 or 8 weeks, and samples were collected for histological and immunohistochemical analyses. … WebThe surgical model of destabilization of the medial meniscus (DMM) has become a gold standard for studying the onset and progression of posttraumatic osteoarthritis (OA).
WebMar 22, 2024 · 22 Mar 2024 All issues ONLINE COVER Mind the gp130. In this image of a mouse knee joint after medial meniscus destabilization, Safranin O staining reveals proteoglycan-rich cartilage (pink) at the joint surface, suggesting resistance to osteoarthritis. WebThis chapter describes the surgical procedure for destabilization of medial meniscus in mice. Details on subsequent microCT and histological analysis are also provided, as well as details on osteoarthritis evaluation. Related articles Based on techniques Generation and Characterization of Mouse Models for Skeletal Disease
WebApr 7, 2024 · 按文献方法采用内侧半月板失稳(destabilization of medial meniscus，DMM)手术诱导建立KOA模型[9]，简述如下：右膝关节内侧髌韧带与内侧副韧带之间开0.5 cm切口，显微镜下暴露、剪断内侧半月板胫骨韧带，缝合切口。 WebApr 1, 2024 · Methods Destabilization of the medial meniscus (DMM) or sham surgeries were performed on 10-week-old male wild-type (WT) and Camkk2-/- mice. Half of the DMM-WT mice and all other cohorts ...
WebIn the µCT analysis, destruction of the medial tibial plateau was observed in 4/40 knees, while none were observed in the DMM group. Of the four knees, destruction of the …
WebAnimals (mice or rats) are anesthetized with Isoflurane and the right knee area and lower leg are prepared for surgery. For the surgical destabilization of the medial meniscus (DMM), a skin incision is made from the distal patella to the proximal tibial plateau. The joint capsule immediately medial to the patellar tendon is incised and spread ... google search keywords rankingWebNational Center for Biotechnology Information chicken enchilada bowlsWebFeb 9, 2024 · Age is the primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such as destabilization of the medial meniscus (DMM) used for evaluating … google search liberal biasWebAug 12, 2013 · 1. Make an incision of the skin on the medial side of patellar ligament using a #15 blade. 2. Fold back the skin and locate the patellar ligament (Figure 1). 3. Make an … google search leading to yahooWebJan 1, 2014 · The surgical model of destabilization of the medial meniscus (DMM) has become a gold standard for studying the onset and progression of posttraumatic osteoarthritis (OA). The DMM model … google search length limitWebFeb 9, 2024 · Age is the primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such as destabilization of the medial meniscus (DMM) used for evaluating disease-modifying OA targets are ... google search liftWebJul 6, 2024 · Destabilization Medial Meniscus Cartilage Scratch Murine Model. JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch … google search launched