WebApr 13, 2024 · Specifically, we calibrated the rate ratio (RR) for ASCVD events associated with a 39 mg/dL reduction in LDL-C from a meta-analysis by the Cholesterol Treatment … WebJul 1, 2012 · Researchers from the Cholesterol Treatment Trialists' (CTT) Collaboration have argued for maximal lowering of low-density lipoprotein cholesterol (LDL-C) by the …
Cholesterol — Clinical Trial Service Unit
WebApr 10, 2024 · ‘We included 21 statin trials in our analysis. We appraised the quality of these studies and found them to be largely at low risk of bias. We conducted a meta-analysis on 19 of the 21 trials that reported data on all-cause … WebFeb 4, 2024 · In the 28 trials of 186,854 participants, 8% (14,483) were >75 years at baseline and median follow-up was 4.9 years. There was a 21% proportional reduction in major CVEs per 1.0 mmol/L reduction in LDL-C, which decreased insignificantly with age and significantly in all age groups. Overall, statin or more intensive statin therapy yielded … dan o\u0027connell ennis
The effects of lowering LDL cholesterol with statin therapy in peopl…
WebFeb 19, 2024 · 7 systematic reviews [11-135 randomized controlled trials (RCTs); 18,192-192,977 patients] from the last 5 years. 1-7 Focusing on the most recent (23 RCTs; 154,664 patients x4.3 years). 1 Results statistically significant unless indicated. Any muscle symptoms, statin versus placebo, WebJul 1, 2012 · Researchers from the Cholesterol Treatment Trialists' (CTT) Collaboration have argued for maximal lowering of low-density lipoprotein cholesterol (LDL-C) by the use of pharmacologic agents, with the strongest evidence coming from the five comparison statin studies in their second meta-analysis. WebNov 27, 2024 · Elevated LDL cholesterol and increased risk of myocardial infarction and atherosclerotic cardiovascular disease in individuals aged 70–100 years: a contemporary primary prevention cohort ... as observed in the Cholesterol Trialist Collaboration meta-analyses. 18 Moderate-intensity statin therapy was expected to reduce LDL cholesterol … dan o\u0027connell hotel carlton